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CLOVES is caused by a genetic mutation (an error in a person's genes). Sometimes, like with CLOVES, genes can mutate (change) on their own, with no known reason. This is called a sporadic mutation. It is not hereditary (passed down by parents to their children).
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Medically reviewed by: Joshua J. Zaritsky, MD, PhD
Date reviewed: August 2025
Note: All information is for educational purposes only. For specific medical advice,
diagnoses, and treatment, consult your doctor.
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